Maija Dambrova Selected Research

Ischemia

12/2023	Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats.
1/2022	Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling.
1/2021	Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury.
1/2020	The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats.
10/2019	Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury.
1/2014	The heart is better protected against myocardial infarction in the fed state compared to the fasted state.
6/2013	Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
6/2012	The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
8/2009	Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
8/2004	Investigations on the pharmacology of the cardioprotective guanidine ME10092.

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Maija Dambrova Research Topics

Disease

12	Infarction (Infarctions) 12/2023 - 06/2002
12	Ischemia 12/2023 - 06/2002
7	Insulin Resistance 03/2022 - 11/2016
7	Inflammation (Inflammations) 12/2021 - 12/2005
7	Type 2 Diabetes Mellitus (MODY) 12/2020 - 08/2009
6	Reperfusion Injury 12/2023 - 08/2009
6	Hypoxia (Hypoxemia) 12/2023 - 01/2014
5	Seizures (Absence Seizure) 01/2023 - 09/2010
5	Myocardial Infarction 01/2021 - 08/2009
5	Atherosclerosis 11/2016 - 01/2009
5	Encephalitis (Encephalitis, Rasmussen) 04/2010 - 12/2005
4	Pain (Aches) 03/2021 - 10/2006
4	Hyperglycemia 01/2021 - 05/2011
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 11/2014
4	Diabetes Complications 02/2013 - 08/2009
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 12/2023 - 09/2011
3	Mitochondrial Diseases (Mitochondrial Disease) 12/2020 - 02/2017
3	Heart Failure 12/2020 - 11/2016
3	Necrosis 10/2020 - 08/2009
3	Body Weight (Weight, Body) 01/2020 - 12/2007
3	Cardiac Arrhythmias (Arrythmia) 11/2016 - 06/2002
2	Neuroinflammatory Diseases 01/2024 - 01/2004
2	Traumatic Brain Injuries (Traumatic Brain Injury) 10/2021 - 01/2020
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 01/2017
2	Hyperlipidemias (Hyperlipidemia) 12/2020 - 05/2011
2	Glucose Intolerance 09/2017 - 05/2011
2	Obesity 01/2017 - 05/2011
2	Weight Gain 01/2017 - 05/2011
2	Brain Ischemia (Cerebral Ischemia) 11/2016 - 09/2011
2	Atherosclerotic Plaque (Atheroma) 09/2015 - 01/2009
2	Hypertension (High Blood Pressure) 01/2014 - 01/2011
2	Coronary Occlusion 08/2009 - 06/2002
1	Liver Failure 04/2024
1	Fatigue 01/2024
1	Post-Acute COVID-19 Syndrome 01/2024
1	Stomach Neoplasms (Stomach Cancer) 04/2023
1	Neoplasms (Cancer) 04/2023
1	Thyroid Diseases (Thyroid Disease) 01/2023
1	Autism Spectrum Disorder 01/2023
1	Reflex Epilepsy (Photosensitive Epilepsy) 01/2023
1	Brain Diseases (Brain Disorder) 01/2023
1	Epilepsy (Aura) 01/2023
1	Mental Disorders (Mental Disorder) 07/2022
1	Anhedonia 07/2022
1	Adenocarcinoma 01/2022
1	Hypertrophy 12/2021
1	Pulmonary Hypertension 12/2021
1	Ventricular Dysfunction 12/2021
1	Left Ventricular Dysfunction 12/2021
1	COVID-19 12/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021

Drug/Important Bio-Agent (IBA)

16	Carnitine (L-Carnitine)FDA LinkGeneric 04/2023 - 12/2006
14	3-(2,2,2-trimethylhydrazine)propionateIBA 12/2021 - 08/2002
12	Fatty Acids (Saturated Fatty Acids)IBA 04/2024 - 08/2009
10	Glucose (Dextrose)FDA LinkGeneric 04/2024 - 08/2009
9	acylcarnitineIBA 12/2023 - 09/2015
8	trimethyloxamine (trimethylamine N-oxide)IBA 04/2023 - 10/2013
5	4-amino-3-phenylbutyric acid (phenibut)IBA 09/2020 - 03/2008
5	MelanocortinsIBA 01/2010 - 01/2004
4	methyl-gamma-butyrobetaineIBA 12/2023 - 09/2015
4	Sigma-1 ReceptorIBA 01/2023 - 01/2017
4	LigandsIBA 01/2023 - 01/2010
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2017
4	Insulin (Novolin)FDA Link 06/2021 - 01/2014
4	Peptides (Polypeptides)IBA 01/2020 - 01/2004
4	Blood Glucose (Blood Sugar)IBA 01/2017 - 08/2009
4	Melanocortin Receptors (Melanocortin Receptor)IBA 01/2010 - 12/2005
3	gamma-butyrobetaine (butyrobetaine)IBA 04/2023 - 12/2006
3	Pyruvic Acid (Pyruvate)IBA 01/2021 - 10/2020
3	SaltsIBA 12/2020 - 08/2009
3	LipopolysaccharidesIBA 10/2020 - 12/2007
3	1- (3,4- dimethoxy- 2- - chlorobenzylideneamino)guanidineIBA 04/2010 - 06/2002
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2010 - 06/2006
2	Neuroprotective AgentsIBA 10/2021 - 11/2016
2	Pentylenetetrazole (Metrazol)IBA 01/2021 - 10/2015
2	imidazole mustard (BIC)IBA 01/2021 - 01/2017
2	LipidsIBA 12/2020 - 01/2019
2	Interleukin-1beta (Interleukin 1 beta)IBA 10/2020 - 04/2010
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 10/2020 - 04/2010
2	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 05/2011
2	Dizocilpine Maleate (Dizocilpine)IBA 12/2019 - 10/2019
2	PalmitoylcarnitineIBA 09/2017 - 01/2016
2	Apolipoproteins E (ApoE)IBA 09/2015 - 01/2009
2	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 06/2013 - 06/2012
2	EnzymesIBA 05/2013 - 03/2011
2	NF-kappa B (NF-kB)IBA 04/2010 - 12/2005
2	beta-MSHIBA 10/2006 - 12/2005
2	Guanidine (Guanidine Nitrate)FDA Link 08/2004 - 06/2002
1	Acetylcarnitine (Alcar)IBA 01/2024
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2023
1	triphenyltetrazoliumIBA 12/2023
1	SeleniumIBA 01/2023
1	trimethyl-lysine hydroxylaseIBA 01/2023
1	Sucrose (Saccharose)IBA 07/2022
1	C-PeptideIBA 03/2022
1	Insulin-Like Growth Factor I (IGF-1)IBA 03/2022
1	Ketone BodiesIBA 03/2022
1	CytokinesIBA 03/2021

Therapy/Procedure

3	Therapeutics 01/2023 - 01/2020
1	Traditional Medicine (Folk Remedies) 03/2021